Jonathan Savidge and the Syndesi team have developed a portfolio of novel SV2A modulators to treat synaptic transmission deficits associated with cognitive dysfunction across a range of neuropsychiatric and neurodegenerative disorders such as Alzheimer's Disease, Parkinson's Disease, schizophrenia, and depression. Syndesi Therapeutics is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment seen in multiple CNS disorders, including Alzheimers Disease, schizophrenia and depresson. Stabilize. Discover. Novo Holdings A/S is a private limited liability company wholly owned by the Novo Nordisk Foundation. - Deal value of US$ 1 billion with US$ 130 million upfront, - Novo Holdings co-created Syndesi Therapeutics in partnership with UCB Pharma and co-led the Series A financing, - Syndesi's lead program SDI-118 to be accelerated by AbbVie to the benefit of patients suffering from cognitive impairment associated with a range of neurodegenerative and neuropsychiatric diseases. Confo has attracted an international team of accomplished scientists and business professionals to deploy its innovative . It has been a pleasure to partner with Novo Seeds, UCB and our other investors to investigate the potential of SDI-118 in early clinical studies. Bone Therapeutics is a bone cell therapy company specializing in addressing unmet medical needs in the field of orthopaedics and bone diseases. In this process the team has added significant insights into the biology of SV2A and the mechanism of action of the Companys lead program SDI-118. About Syndesi Therapeutics. Now, as part of AbbVie, the programme is well positioned to move into late-stage clinical development.. Syndesi Therapeutics SA, a clinical stage biotechnology company developing novel modulators of the synaptic vesicle protein SV2A for the treatment of cognitive impairment, announces results from two Phase I studies of its lead compound SDI-118, supporting further development of this promising molecule. This acquisition gives AbbVie access to Syndesi's portfolio of novel modulators of the synaptic vesicle protein 2A (SV2A), including its lead molecule SDI-118. AbbVie has acquired Belgium-based company Syndesi Therapeutics in a deal worth up to $1bn, expanding its neuroscience portfolio.. Information about your device and internet connection, like your IP address, Browsing and search activity while using Yahoo websites and apps. Company Type For Profit. Syndesi Therapeutics was established to develop a series of novel, pro-cognitive small molecule SV2A modulators licensed from UCB. Syndesi Therapeutics serves customers worldwide. Sustainable Development Goals.. We focus on therapeutics, diagnostics supporting medical therapies, and sustainable agriculture. When typing in this field, a list of search results will appear and be automatically updated as you type. AbbVie announced it has completed the acquisition of Syndesi Therapeutics SA, which will help to expand AbbVie's neuroscience portfolio. Dyne Therapeutics. COPENHAGEN, Denmark, March 1, 2022 /PRNewswire/ -- Novo Holdings, a leading international life sciences investor, today announces that its portfolio company Syndesi Therapeutics ('Syndesi') has been acquired by AbbVie (NYSE: ABBV) for up to US$1 billion in total deal value with US$ 130 million upfront. Criteria. We worked closely with the Syndesi team and our co-investors through the Company's early development and we are incredibly proud of the progress made. Cision Distribution 888-776-0942 Syndesi Therapeutics is developing molecules that uniquely modulate the synaptic vesicle protein SV2A, which plays a central role in synaptic transmission (the communication between neurons in the brain). Other executives include John Kemp, Chief Scientific Officer; Torsten Madsen, Chief Medical Officer and 4 others. Brussels, Belgium - February 1st, 2018 - The creation of Syndesi Therapeutics ('Syndesi') was announced today as the result of a partnership between UCB and a syndicate of Belgian and international investors.The investor syndicate is led by Novo Seeds and Fountain Healthcare together with Johnson & Johnson Innovation - JJDC, Inc. (JJDC), V-BIO Ventures, the Walloon Investment Fund . Further information : www.novoholdings.dk. Founded in December 2017 and based in Belgium, Syndesi is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic . Syndesi is investigating the potential of these molecules to improve cognition in diseases such as Alzheimer's Disease and other dementias, as well as other conditions such as major depression and cognitive . +1 more. The collaborative effort by Novo Seeds and UCB Pharma - alongside a syndicate of Belgian and international investors - enabled Chief Executive Officer Jonathan Savidge and his team to focus on progressing the first-in-class synaptic vesicle protein 2A (SV2A) programme into clinical Phase 1b studies. About Syndesi Therapeutics. AbbVie's acquisition of Syndesi is a testament to our strategy as well as to the leadership team, the assets they developed and the strategy they executed. Provides strong support for the initiation of further clinical trials in cognitive impairment. from 8 AM - 9 PM ET. Company profile page for Syndesi Therapeutics SA including stock price, company news, press releases, executives, board members, and contact information You can change your choices at any time by visiting your privacy controls. The Syndesi Therapeutics annual revenue is estimated at < 1M. Syndesi Therapeutics is developing molecules that uniquely modulate the synaptic vesicle protein SV2A, which plays a central role in synaptic transmission (the communication between neurons in the brain). Confo Therapeutics' unparalleled technology stabilizes functional conformations of GPCRs (G protein-coupled receptors) to uncover a wide range of previously inaccessible drug targets. This acquisition gives AbbVie access to Syndesi's portfolio of novel modulators of the synaptic vesicle protein 2A (SV2A), including its lead molecule SDI-118. Developing novel SV2A modulators as potential treatments for cognitive impairment | Syndesi Therapeutics is developing molecules that uniquely modulate the synaptic vesicle protein SV2A, which plays a central role in synaptic transmission (the communication between neurons in the brain). I am delighted with the announcement of this deal. Regulating synaptic transmission represents a promising approach to treating Alzheimer's Disease and other disorders . The collaborative effort by Novo Seeds and UCB Pharma alongside a syndicate of Belgian and international investors enabled Chief Executive Officer Jonathan Savidge and his team to focus on progressing the first-in-class synaptic vesicle protein 2A (SV2A) programme into clinical Phase 1b studies. MT . In this process the team has added significant insights into the biology of SV2A and the mechanism of action of the Company's lead program SDI-118. On Mar 2, 2022. Regulating synaptic transmission represents a promising approach to treating Alzheimer's Disease and other disorders with cognitive impairment. Syndesi has an exclusive license to its platform technology from UCB, the leading company in SV2A research. Jonathan Savidge and the Syndesi team have developed a portfolio of novel SV2A modulators to treat synaptic transmission deficits associated with cognitive dysfunction across a range of neuropsychiatric and neurodegenerative disorders such as Alzheimers Disease, Parkinsons Disease, schizophrenia, and depression. MT-2000 is a class of agents that are designed to precisely convert pro-inflammatory M1 Macrophages to anti-inflammatory M2 macrophages. Macrophage Therapeutics has developed a proprietary targeted steroid (MT-2000 class) designed to specifically treat the disease-causing cells quarterbacking the body's inflammatory response (Macrophages). AbbVie has bolstered its neuropsychiatric and neurodegenerative portfolio with the acquisition of Belgium-based Syndesi Therapeutics in a deal valued at up to $1 billion. Find out more about how we use your information in our privacy policy and cookie policy. Now, as part of AbbVie, the programme is well positioned to move into late-stage clinical development.". Syndesi Therapeutics is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment. Syndesi Therapeutics is developing molecules that modulate the synaptic vesicle protein SV2A, which plays a central role in synaptic transmission (the communication between neurons in the brain). Rappta's proprietary tools and understanding of the target allow us to therapeutically reactivate PP2A, a critical enzyme . The investment in Syndesi is an integral part of Novo Seeds' approach to new venture formation by co-leading spinouts from pharmaceutical companies based on assets that are no longer in-line with the corporation's overall strategy. Regulating synaptic transmission represents a promising approach to treating Alzheimers Disease and other disorders with cognitive impairment. Novo Holdings also manages a broad portfolio of diversified financial assets. They are also entitled to get further contingent payments of up to $870m on meeting specific pre-set milestones. Acquiring Organization: AbbVie AbbVie is a pharmaceutical company that discovers, develops, and markets both biopharmaceuticals and small molecule drugs. Environmental, Social and Governance (ESG), HVAC (Heating, Ventilation and Air-Conditioning), Machine Tools, Metalworking and Metallurgy, Aboriginal, First Nations & Native American. About Syndesi Therapeutics. Syndesi Therapeutics SA operates as a biotechnology company. Christian Mostrup, Senior Programme Lead, Communications, Novo Holdings, +45 3067 4805,cims@novo.dk. profile, Go to We worked closely with the Syndesi team and our co-investors through the Companys early development and we are incredibly proud of the progress made. As one of the leading pharmaceutical companies in CNS drug development globally, AbbVie makes the perfect partner to maximize the potential benefit of Syndesis lead candidate, SDI-118, for the treatment of cognitive impairment across multiple diseases.. Syndesi Therapeutics is developing molecules that uniquely modulate the synaptic vesicle protein SV2A, which plays a central role in synaptic transmission (the communication between neurons in the brain). We invest in private companies with differentiated technology addressing unmet needs. Founded in December 2017 and based in Belgium, Syndesi is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment. The Company's approach is aimed at treating Alzheimer's Disease and other disorders with cognitive impairment. Syndesi Therapeutics is one of several Novo Seeds portfolio companies focused on developing better treatments for CNS disorders, an area of significant unmet medical need. Syndesi was created in 2018 as the result of a close collaboration between Novo Seeds, the company creation arm of Novo Holdings, and UCB Pharma, the Belgium-based global pharmaceutical company. Founded in December 2017 and based in Belgium, Syndesi is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment. Click Manage settings for more information and to manage your choices. I am delighted with the announcement of this deal. Description. Celebrity tailor and designer Rich Fresh has made a name for himself in Los Angeles as a luxury athleisure designer. Our ultimate goal is to bring a new generation of life-changing treatment options . Morten Graugaard Dssing, Board Director of Syndesi and Partner at Novo Holdings, said: Spin-out ventures from pharmaceutical companies are an integrated part of Novo Seeds company creation strategy, where we aim to add significant strategic and operational support to the spin-out process. The Company specializes in neurology drug discovery to develop potential therapeutics in cognitive disorders. Syndesi Therapeutics General Information. As a life science investor, Novo Holdings provides seed and venture capital to development-stage companies and takes significant ownership positions in growth and well-established companies. Founded in December 2017 and based in Belgium, Syndesi is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic . Dyne Therapeutics is a developer of targeted therapies intended for serious muscle diseases. Phone Number +32 10 280 238. We, Yahoo, are part of the Yahoo family of brands. About Syndesi Therapeutics. ABBV ie (NYSE: ABBV) today announced it has completed the acquisition of Syndesi Therapeutics SA, which will help to expand ABBV ie's neuroscience portfolio. Jonathan Savidge, Chief Executive Officer, Syndesi Therapeutics, said: "We have been impressed with the vision of AbbVie's neuroscience R&D team, who share our view on the therapeutic potential of SDI-118 in a range of neurologic diseases. Syndesi Therapeutics's Chief Executive Officer is Jonathan Savidge. There is a major unmet need for new therapies that can . The only daily news program focused exclusively on technology, innovation and the future of business from San Francisco. According to the deal, shareholders of Syndesi will receive an upfront payment of $130m from AbbVie. Jonathan Savidge, Chief Executive Officer, Syndesi Therapeutics, said: "We have been impressed with the vision of AbbVie's neuroscience R&D team, who share our view on the therapeutic potential of . We are working on a first-in-class series of anti-cancer molecular glues that reactivate a key tumor suppressor, protein phosphatase 2A (PP2A). Medical. Morten Graugaard Dssing, Board Director of Syndesi and Partner at Novo Holdings, said: "Spin-out ventures from pharmaceutical companies are an integrated part of Novo Seeds' company creation strategy, where we aim to add significant strategic and operational support to the spin-out process. 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