The purpose of this study was to examine the gaze stabilization test (GST) in those referred for vestibular physical therapy following concussion, to determine the association between GST and other measures of recovery following concussion, and to examine the effect of demographic variables on GST performance. PMC The present study details the use of GST in patients with concussion and demonstrates an association with common outcome measures in vestibular rehabilitation. Third, provide normative data. Gaze stabilization: Standing feet apart 2020 Mar;42:68-74. doi: 10.1016/j.ptsp.2020.01.001. Vestibular Loss:Unilateral or Bilateral vestibular hypofunction (Whitney 2009;n= 12 patients with UVH or BVH; mean age 70.1 (6.6) years;n= 20 controls mean age = 70 (5.3) years). Patient should be cleared of vascular and orthopedic contraindications (i.e. Voelker CC, Lucisano A, Kallogjeri D, Sinks BC, Goebel JA. official website and that any information you provide is encrypted Vestibulo-ocular dysfunction in mTBI: Utility of the VOMS for evaluation and management - A review. Given the fixed optotype size presented during testing, the GST may be preferable to other behavioral measures of VOR function (e.g. GST results in response to yaw and pitch plane head movements identified subjects with TUG and DGI performance deficits (*p< 0.05). Conclusion: % Left/Right Symmetry Differences in maximum gaze velocity between the two directions of a given axis are expressed as a percentage of the sum of the two velocities. or placed on wall to side for . HGST and VGST had a weak positive correlation to the Activities-Specific Balance Confidence Scale (r = 0.20, r = 0.21) and weak negative correlation to the Dizziness Handicap Inventory (r = -0.18, r = -0.22). BMJ Open. 2020;30(4):249-257. doi: 10.3233/VES-200710. Gaze testing is the ONLY test of the four ocular tests in which an abnormal result could be generated either from the peripheral vestibular system or from the central vestibular system. Horizontal and vertical GST scores (HGST and VGST), neurocognitive testing results, and demographic data were extracted retrospectively from the patient health record. Oculomotor Strategies and Their Effect on Reducing Gaze Position Error, Stride cycle influences on goal-directed head movements made during walking, Role of Electrically Evoked Auditory Brainstem Response in Cochlear Implantation of Children With Inner Ear Malformations, Effect of unilateral vestibular deafferentation on the initial human vestibulo-ocular reflex to surge translation. official website and that any information you provide is encrypted checkerboard) 4. Normal Response:Average abilities range from 75-105 deg/sec. Unable to load your collection due to an error, Unable to load your delegates due to an error. athletes) can achieve velocities up to 160 deg/sec). Vestibular Ocular Reflex (VOR) Exercise/ Gaze Stabilisation Exercise. seconds. Participants in this study were recruited from the clinical practice of the author. A patient with normal gaze ability will produce a tracing that is virtually a straight line once the eyes are fixated on the target. Federal government websites often end in .gov or .mil. Enter the email address you signed up with and we'll email you a reset link. The goal of the gaze stabilization exercise is to improve the interaction between the visual The Non-Concordance of Self-Reported and Performance-Based Measures of Vestibular Dysfunction in Military and Civilian Populations Following TBI. A new dynamic visual acuity test to assess peripheral vestibular function. Gaze Stabilization Test is a reliable specific test of gaze stability which has diagnostic and rehabilitative applications in patients with vestibular dysfunction and reduced contralesional velocities may help explain oscillopsia in Patients with unilateral dysfunction. Categories Neuroscience Physiology. Oculomotor Deficits and Symptom Severity Are Associated With Poorer Dynamic Mobility in Chronic Mild Traumatic Brain Injury. You can try this exercise in the comfort of your own home. The GST is a computer-based testing platform and head mounted rate sensor that measures the most rapid head movement velocity at which the patient is able to correctly maintain visual acuity on a fixed optotype size. In this free tutorial you'll find a really simple way to strengthen your muscles in your neck . Purpose: The purpose of this study was to examine the gaze stabilization test (GST) in those referred for vestibular physical therapy following . DVA evaluates accuracy of visual acuity during fixed velocity head movements. Federal government websites often end in .gov or .mil. Otol Neurotol. Functional Gait Assessment Timed Up and Go Test (TUG) Timed Up and Go Test- Dual Task (Dual Task TUG) 10 Meter Walk Test 5x sit to stand To do this exercise you will need to sit facing a blank wall and hold out your thumb straight in front of you (figure 1). Intervention(s): "Gaze stabilization test: a new clinical test of unilateral vestibular dysfunction." Repeated video head impulse testing in patients is a stable measure of the passive vestibulo-ocular reflex. (2011). Accessibility Disclaimer, National Library of Medicine A patients SVA becomes his or her reference condition for dynamic testing. , Brach J.S. Academia.edu no longer supports Internet Explorer. Philanthropic support truly drives our mission and vision. Bookshelf 2021 Jan;278(1):41-48. doi: 10.1007/s00405-020-06052-1. The name "gaze stabilization" may imply help with vision impairment issues - however, this treatment path uses gaze to help mitigate feelings of dizziness and nausea caused by conditions like: vestibular neuritis Central vestibular disorders Acoustic neuroma (swelling or cancer in the 8th nerve) What conditions aren't helped by gaze stabilization? Please enable it to take advantage of the complete set of features! Unable to load your collection due to an error, Unable to load your delegates due to an error. Would you like email updates of new search results? For the dynamic testing component, the examiner determines the plane of head movement (i.e., yaw, or east-west; pitch, or north-south, or roll alternating ear to shoulder) and orients the patient to the axis of head movement for the testing condition. Similarly, benign paroxysmal positional vertigo, visual motion sensitivities, and difficulties with gaze stabilization are also common following SRC [ 9 ]. Concussion can cause vestibular dysfunction and oculomotor abnormalities which can lead to dizziness and protracted recovery time. 1 by U.S. News & World Report for 31st Consecutive Year, Community-Ready Upper Extremity Interactive Rehabilitation, Dr. Lieber To Receive AACPDM's Lifetime Achievement Award for Research on Cerebral Palsy, Global Advisory Services Hospital Training & Consulting, Medical Student Education & Residency Program, 1 Year Webinar Package - Unlimited Access, http://www.neuropt.org/go/healthcare-professionals/neurology-section-outcome-measures-recommendations, Making Waves Following a Spinal Cord Injury, Full Circle After a Non-Traumatic Brain Injury, An Unanticipated Head Injury and Incredibly Bright Future. sharing sensitive information, make sure youre on a federal NCI CPTC Antibody Characterization Program. Spearman non-parametric correlation coefficients (and significance Levels) for associations between average GST results (degrees/sec) for yaw and pitch and measures of dynamic gait performance in patients with vestibular disorders and control subjects. Correlations between GST velocity and neurocognitive test results and between GST and patient-reported outcomes were examined. Future studies should examine nonhealthy populations as well as young children and older adults. The average slow phase velocity value(s) will be plotted in the bar graphs to the right of the tracings. An official website of the United States government. This exercise is intended only for patients who were instructed to do this specific exercise by a University of Michigan Vestibular Testing Center clinician. Download Free PDF. Dynamic visual acuity (DVA) testing is a sensitive assessment tool for detecting VOR impairments. Neil Shepard. "Physical performance and a test of gaze stabilization in older adults." Conclusion: GST is a reliable specific test of gaze stability which has diagnostic and rehabilitative applications in patients with vestibular dysfunction. Opp Metro Pillar 1670 Gaze Stabilization Exercise VORx1 Purpose: To improve ability to focus eyes when your head is moving. Date. View PDF; Download Full Issue; Neuroscience. II. Background: The purpose of this pilot study is to analyze the differences of baseline gaze stabilization in various competitive levels of soccer participant, to determine whether there could be a relationship between higher level of play and increased gaze stability. Thanks for helping us invest in our patients. Otol Neurotol 29(7): 982-988. GAZE STABILIZATION 1645 Subjects were instructed to look passively "through" holder position signal).ES and EH were characterized in the pattern (in order to prevent them from actively terms of gain (ratio of ES [EH] fundamental to VS [VH] tracking an item of the pattern; compare with the fundamental, respectively) and phase (phase . An official website of the United States government. The Journal of Rehabilitation Research and Development, Archives of OtolaryngologyHead & Neck Surgery, Maurizio Versino, Silvia Colnaghi, Paolo Colagiorgio. Pritcher et al 2008, (n= 20 young controls,n= 21 elderly controls,n= 16 patients with vestibular disease (n= 12 UVH, 1 BPPV, 2 BVH, 1 multisensory dysequilibrium) Cut-point for of velocity < 61 d/s and downward; GST velocity was 44% Sn and 90% Sp for identification of patients with vestibular disease with ROC identified maximum LR of 4.5 (95% CI 1.5-13.3) (AUC, 0.73; 95% CI, 0.59-0.88 p < 0.01) (Adequate validity). (2009). Clipboard, Search History, and several other advanced features are temporarily unavailable. The purposes of this dissertation were threefold; first the reliability of GST and DVA test were examined. Optotypes only present when one meets or exceeds the minimum specified rotational velocity threshold for that condition as measured by head mounted rate sensor. 2021 Feb 9;12:635305. doi: 10.3389/fneur.2021.635305. Goebel 2006, N = 28 (14 patients with vestibular loss of > 50%, 14 healthy controls) GST demonstrated 93% specificity, 64% sensitivity, and a reliability index of 0.91 for the detection of unilateral dysfunction with ipsilesional movement. Impairments of the vestibular-ocular reflex (VOR) lead to a decline in visual acuity during head movements. For testing, the examiner first establishes Static Visual Acuity (SVA) on a computer monitor at a distance of 10 feet by displaying sequences of the optotype "E" of predetermined size and in one of four possible random orientations. Repeat using full field stimulus . Intraclass correlation coefficient (95% confidence intervals). Eyes closed (this is for practice of mental imagery) 2. blank background 3. busy background (i.e. government site. Female adolescents demonstrate greater oculomotor and vestibular dysfunction than male adolescents following concussion. 2!! Future work is needed to further evaluate the role of GST in concussion management. DVA) among patients with significant co-morbid visual deficits. , Mohammed M.T. Physical Therapy, University of Jordan, 2003 M.Sc. Therefore, it is imperative to equip sports medicine clinicians with clinical strategies to identify, assess, and manage symptoms and impairments stemming from vestibular and ocular dysfunction. Find it on PubMed, Ward, B. K., Mohammed, M. T., et al. Look OKN (aka Active or Voluntary OKN) Subject is instructed to look at the moving targets. GST is a reliable specific test of gaze stability which has diagnostic and rehabilitative applications in patients with vestibular dysfunction. Comparison of the gaze stabilization test and the dynamic visual acuity test in unilateral vestibular loss patients and controls. Study sample: Repeat while moving head up . Both the DV A test and GST assess similar yet distinct manifestations of gaze stability in peripheral vestibular deficits and are described later in greater detail (Goebel et al., 2007). Tape a card with one letter or word onto the wall at eye level. 2010 Jul;136(7):686-91. doi: 10.1001/archoto.2010.99. One hundred fifty-eight individuals who sustained a concussion and were referred to vestibular physical therapy. Gaze stabilization test (GST) and dynamic visual acuity (DVA) test are functional measures of the vestibulo-ocular reflex which helps to maintain clear vision during head . An abnormal gaze tracing might present itself in several ways. It is an assessment for left, right, up, and downward directed head movements as well as left and right roll. Publication types Controlled Clinical Trial MeSH terms Adult Aged Female 11 most studies that. . GST continues until the patient fails to correctly identify the orientation of at least 3 of 5 optotypes thereby establishing gaze stability at the fastest head movement velocity at which the minimum number of optotypes were correctly identified. FOIA Neck Strength Excercises. 2016 Sep;51(9):739-742. doi: 10.4085/1062-6050-51.12.01. You can download the paper by clicking the button above. Otorhinolaryngology Neuroscience Sensory Systems . Front Neurol. Ltd. (Main Office) 701, First Floor, Malik Solitaire, Road No: 36, Jubilee Hills, Hyderabad - 500034. Setting: University Athletic Medicine Facility. These recommendations were developed by a panel of research and clinical experts using a modified Delphi process. The Gaze Stabilization test (GST) was introduced as new functional evaluation of a person's ability to use the VOR for appropriate visual target capture during head movements through FDA approved. Identification of persons with unstable gait using the timed up and go and DGI performance concurrent with GST head movements. We have reviewed nearly 300 instruments for use with a number of diagnoses including stroke, spinal cord injury and traumatic brain injury among several others. Badaracco C, Labini FS, Meli A, De Angelis E, Tufarelli D. Otol Neurotol. Gaze Stabilization Test Asymmetry Score as an Indicator of Previous Concussion in a Cohort of Collegiate Football Players. K01 DC012332/DC/NIDCD NIH HHS/United States, P30 AG024827/AG/NIA NIH HHS/United States, NCI CPTC Antibody Characterization Program. 2021 Jul;16(3):128-137. doi: 10.1016/j.joto.2020.12.002. Before Wagner AR, Akinsola O, Chaudhari AMW, Bigelow KE, Merfeld DM. This short video tutorial provides an overview of the concept of the auditory steady state response (ASSR) test. Reduced contralesional velocities may help explain oscillopsia in patients with unilateral dysfunction. Gaze stabilization test (GST) and dynamic visual acuity (DVA) test are functional measures of the vestibulo-ocular reflex helps to maintain clear vision during head which movement. Below are examples of abnormal tracings: Gaze test showing bilateral gaze-evoked nystagmus, Gaze test showing down-beating nystagmus on gaze down 20. 2021 Jul 26;12:642457. doi: 10.3389/fneur.2021.642457. See table below. Age related differences were also examined across variables for two groups (under 30 and over 30) using test analysis. The site is secure. In 2004, Treleaven, Jull and Choy investigate the presence of deficits in gaze stability and smooth pursuit neck torsion in relation to WAD and dizziness. Clipboard, Search History, and several other advanced features are temporarily unavailable. There were no significant differences for age group on all DVA variables (p > .05). Second, to examine reliability of the tests. J Vestib Res 20(5): 363-372. Correct identification of optotype orientation over 3 of 5 successive "E" presentations confirms visual acuity at the specified level of visual acuity. Journal of vestibular research : equilibrium & orientation, 2010. The purpose of this study was to examine the gaze stabilization test (GST) in those referred for vestibular physical therapy following concussion, to determine the association between GST and other measures of recovery following concussion, and to examine the effect of demographic variables on GST performance. Age effect on the Gaze Stabilization test. A patient may present with square wave jerks, nystagmus, or gaze decay. Tertiary academic referral laboratory. Peak head velocity in healthy subjects averaged 147 degrees per second, whereas ipsilesional velocities dropped significantly to an average of 84 degrees per second. Gray M, Wilson JC, Potter M, Provance AJ, Howell DR. Phys Ther Sport. Pritcher 2008,N = 57, (20 young controls 20-40 yrs, 21 elderly controls (60- 80 yrs), and 16 patients with vestibular disease (20-80 yrs). The inability to maintain a steady gaze is an indication of either a central or peripheral vestibular system lesion. STABILIZER DESIGN Sensors for control and navigation must be mounted onto the microrobot for future autonomous navigation and stabiliy. In 2021, your cash gifts may also favorably impact your taxes, thanks to the extension of many of the charitable provisions in the Coronavirus Aid, Relief and Economic Security (CARES) Act. (2005). Assess angular vestibulo-ocular reflex (aVOR) contributions to gaze stability during high frequency and velocity head rotation. the method includes measuring the subject's static visual acuity to obtain an assessment, setting at least one test parameter based on the assessment, measuring the subject's dynamic visual. Results: Optotype size is progressively reduced in successive conditions and visual acuity is re-assessed with the next smaller optotype until its orientation can no longer be reliably determined. "The reliability and response stability of dynamic testing of the vestibulo-ocular reflex in patients with vestibular disease." Do you see an error or have a suggestion for this instrument summary? Relationship Between Cognitive Assessment and Balance Measures in Adolescents Referred for Vestibular Physical Therapy After Concussion. GAZE STABILIZATION TEST: RELIABILITY, RESPONSE STABILITY, PERFORMANCE OF HEALTHY SUBJECTS AND PATIENTS WITH CONCUSSION by Maha Tayseer Mohammad B.Sc. The GST minimizes contributions from vestibular catch upsaccades or preprogrammed saccades by randomly displaying a visual optotype for a brief period (75 ms) during active head movement,making the task unpredictable in timing and direction. Vestibular rehabilitation outcomes in chronic vertiginous patients through computerized dynamic visual acuity and Gaze stabilization test. 8600 Rockville Pike Or Call Toll-Free Bethesda, MD 20894, Web Policies The stimulus is a vertical or horizontal head movement at controlled, criterion velocities while viewing a visual optotype (letter E). The .gov means its official. Scoring: GST performance is evaluated based on Maximum Gaze Velocity Achieved and Symmetry (for Left and Right head movements). Keep eyes fixed on single stationary target held in hand . The gaze-stabilization test (GST) was used to assess the VOR contribution to visual acuity, defined by the peak velocity of head rotation possible while maintaining visual fixation [14].. GST uses a fixed optotype size to provide a quantifiable behavioral measure of aVOR function by direction and head movement velocity. Normative data for each variable report means, standard deviations and ranges for participants aged 1844 years. Results provide insight into a patient's effective use of VOR as it relates to functional demands for activities of daily living, and clinicians can use the data to make training decisions and document progress. The .gov means its official. (2007). A total of 87 healthy adult volunteers were included in this study. 8600 Rockville Pike (Y/N), Is additional research warranted for this tool (Y/N). All participants were tested on the RightEye Dynamic Visual Acuity Tests to determine reliability via Cronbachs Alpha and Intraclass correlation coefficients (ICC). This course provides an overview of the basics of performing the auditory steady state response (ASSR) test. Epub 2020 May 24. Maximum Gaze Velocity Separate graphs of GST results are provided for each axis of head movement. (2010). doi: 10.1136/bmjopen-2021-049560. Frequency is about 1 Hz. Sorry, preview is currently unavailable. Alsalaheen BA, Whitney SL, Marchetti GF, Furman JM, Kontos AP, Collins MW, Sparto PJ. The right eye is represented by the red line and the left eye by the blue line. Intraclass correlation coefficient (ICC) for GST performed on the same day (within session) after a 30 minute rest break and after 7-10 days (between sessions). The mean time from injury to GST was 215 days (SD = 241) and the mean time from physical therapy evaluation to GST was 48 days (SD = 54). The correct SVA test is then based on the least knowledge, only a few publications have utilized both DVA optotype rightly recognized by the subject: for this reason the and the Oscillopsia Score (OS) to asses oscillopsia but optotype "E" is shown on the computer monitor with random without significant relationship between subjective and. Disclaimer, National Library of Medicine Quintana C, Heebner NR, Olson AD, Abt JP, Hoch MC. Surprisingly, peak velocities were also significantly reduced to an average of 112 degrees per second with contralesional movements. The inability to maintain a steady gaze is an indication of either a central or peripheral vestibular system lesion. Bethesda, MD 20894, Web Policies Data was collected with multiple testers and still showed excellent reliability. Sport-specific differences in dynamic visual acuity and gaze stabilization in division-I collegiate athletes. You will see a green dot on the screen. grocery store) Toll-Free U.S. FOIA (Y/N), Students should be exposed to tool? Bookshelf Mohammad et al 2011n= 29 patients with vestibular disease (1678 years) participated (n= 16 peripheral vestibular disorders,n= 9 central vestibular disorders, andn= 3 mixed central /peripheral vestibular disorders. There are few clinically useful, functional measures of the vestibulo-ocular reflex (VOR) post-concussion. The gaze stabilization test (GST) requires the maintenance of fixation on a fixed target size during active head movement. Address. Find it on PubMed. Data collection and analysis: To browse Academia.edu and the wider internet faster and more securely, please take a few seconds toupgrade your browser. Purpose: HHS Vulnerability Disclosure, Help Volume 408, 1 June 2019, Pages 418-429. . GST demonstrated 93% specificity, 64% sensitivity, and a reliability index of 0.91 for the detection of unilateral dysfunction with ipsilesional movement. Results indicate that patients who achieved higher velocities on GST perceived lower handicap due to dizziness and had higher confidence in their balance. (2010). Gain is about 0.5 even for lower velocities, meaning that the image is slipping on the retina. Research design: Front Neurol. Results: MeSH In contrast, the Gaze Stabilization test (GST) is a new functional evaluation of the VOR that identifies a person's maximum head velocity (in degrees per second) a person can maintain with stable vision of a target (i.e. This site needs JavaScript to work properly. March 1, 2005. Reporting of exercise dose and dosage and outcome measures for gaze stabilisation in the literature: a scoping review. J Athl Train. Vital D, Hegemann SC, Straumann D, Bergamin O, Bockisch CJ, Angehrn D, Schmitt KU, Probst R. Arch Otolaryngol Head Neck Surg. Matthew R Scherer PT, PhD, NCS Jennifer L. Stoskus PT, MSPT, DPT. Physical Therapy, University of Pittsburgh, 2006 Submitted to the Graduate Faculty of School of Healthy and Rehabilitation Sciences in partial fulfillment of the requirements for the degree of . [43] Ward B.K. 2022 Jul 19;13:904593. doi: 10.3389/fneur.2022.904593. The https:// ensures that you are connecting to the Diagnostic test protocol with computerized system of target presentation and head velocity monitoring. sharing sensitive information, make sure youre on a federal Gaze stability and smooth pursuit neck torsion (oculomotor system). Male patients achieved significantly higher velocities than female patients on HGST and VGST (p = 0.02, p = 0.01). 17-20 we found the mean peak head turning velocities in the yaw and pitch planes during vorx1 exercises in the early session were 100.2/s and 79.3/s, square wave jerks or nystagmus). government site. 1-844-355-ABLE. Vestibular rehabilitation (VR) is a specialized form of therapy intended to alleviate both the primary and secondary problems due to vestibular disorders. The site is secure. 2010, Journal of vestibular research : equilibrium & orientation. Try not to move your head.. Amplitude is 5-10 deg, as subject tracks over a significant range. Gaze stability is assessed at progressively faster speeds until the patient fails to correctly identify the orientation of the E optotype in 3 of 5 presentations. Gaze Stabilization Exercises for the Inner Ear (Eye-Head Coordination) Practice head-eye coordination to help your brain (cerebellum) get better at keeping your eyes focused while your head is moving. Otol Neurotol 31(1): 168-172. Central Oscillopsia: visual blurring with head movement Decreased VOR gaze stability with head motion Patient report of environment moving or oscillating, as they walk through it. Participants (n = 138) were males (n = 83) and females (n = 55) between the ages of 1844 years old. 2015 Apr;36(4):746-53. doi: 10.1097/MAO.0000000000000689. This site needs JavaScript to work properly. These distances were chosen to test how gaze stabilization is adapted to cope with targets that are approximately half and double the vertical head fixation distance (HFD). The objective of this study was to evaluate the effect of age on the GST in participants without vestibular disease. High performance individuals (i.e. Differences in GST performance among patient subgroups were examined using one-way analysis of variance. Wood NI, Hentig J, Hager M, Hill-Pearson C, Hershaw JN, Souvignier AR, Bobula SA. Find it on PubMed, Pritcher, M. R., Whitney, S. L., et al. Patient instructions "You will see a green dot on the screen. Retrospective chart review. SVA is established as the smallest "E" that can be accurately and consistently identified. The reliability, stability, and concurrent validity of a test of gaze stabilization, J Vestib Res 20 (2010), 363-372. optotype). "Comparative study of the Gaze Stabilization Test (GST) and the Dynamic Visual Acuity Test (DVAT) for detecting patients with unilateral vestibular dysfunction. Find it on PubMed, Whitney, S. L., Marchetti, G. F., et al. If this is an emergency, please dial 911, A Young Scientist's Journey after a Stroke, Care by the Numbers: Skilled Nursing versus Inpatient Rehabilitation, WSJ: Recognizing Aphasia and Seeking Treatment, Shirley Ryan AbilityLab Ranked No. Best Practices in Gaze Stabilization Tests Static position test - Record eye movements with and without fixation as the patient holds different head positions (at least 4 head positions) 1. the goal for angular head velocity during gaze stabilization exercises was 120/s to emphasize vor gaze stabilization and to generate gaze position errors that would drive saccadic corrections. When the average slow phase velocity exceeds the threshold value of 6/sec, the bar graph will be shaded grey and a red diamond will appear near the bar graph to indicate an out of threshold response. If the dot moves, follow it with your eyes only. Clin J Sport Med. Otol Neurotol 28(1): 68-73. Suite 420 - 233 West First Street, North Vancouver, BC V7B 1M3 tel: 604-983-6616 fax: 1-866-261-0642 info@body-works.ca ! Peripheral or Central Honaker JA, Criter RE, Patterson JN, Jones SM. For detailed information about how recommendations were made, please visit:http://www.neuropt.org/go/healthcare-professionals/neurology-section-outcome-measures-recommendations, Reasonable to use, but limited study in target group / Unable to Recommend. 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